反应详情

To a suspension of N-(2-bromophenethyl)-2,2,2-trifluoroacetamide (8.88 g, 30 mmol) and paraformaldehyde (13.5 g, 0.45 mol) in 45 mL of glacial acetic acid at room temperature was slowly added 30 mL of sulfuric acid (96.6%). After stirring at room temperature overnight, the reaction mixture was quenched with ice water and extracted with EtOAc, washed with brine and Sat. NaHCO3 and dried over Na2SO4. After concentration, flash chomatography (SiO2, hexane/DCM=1:1) gave of 1-(5-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone as a white solid.

1. customthe reaction mixture was quenched with ice water
2. extractionextracted with EtOAc
3. washwashed with brine and Sat. NaHCO3
4. dry with materialdried over Na2SO4
5. concentrationAfter concentration, flash chomatography (SiO2, hexane/DCM=1:1)