HCID 58597258, compound → HCID 58597253, compound

Participants

Reaction Steps

A suspension of 30 mg of Pd/C (10% w/w) in a solution of (R)-7-azido-3-isobutyl-1,2,3,4,7,8,9,10-octahydrobenzo[f]isoquinoline (296 mg, 1 mmol) in 30 mL of EtOAc was stirred under H2 atmosphere overnight. The reaction mixture was then directly submitted to flash chomatograph (SiO2, EtOAc to EtOAc/2M NH3 in MeOH=100:15 to 100:25 to 100:35) to give (R)-3-isobutyl-1,2,3,4,7,8,9,10-octahydrobenzo[f]isoquinolin-7-amine as a colorless oil.

Provenance & Evidence