HCID 86602830, compound → HCID 66926982, compound

Participants

Reaction Steps

A solution of (R)—N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)formamide (45 mg, 238 μmol) in 5 mL of HCl and 5 mL of MeOH was refluxed for 2 h and then stirred at RT overnight. The solvent was evaporated and the residue was neutralized with 10N NaOH and was extracted with EtOAc. The extracts was dried over Na2SO4 and evaporated. flash chomatograph (SiO2, EtOAc to EtOAc/2M NH3 in MeOH=100:10 to 100:20) afforded crude (R)-4-amino-3,4-dihydronaphthalen-1(2H)-one as a sticky oil.

Provenance & Evidence