Sodium Hydroxide → HCID 178510755, compound

HRID 1444707Notes

Reaction equation

HRID 1444707 reaction equation
[N:1]1[N:2]=[C:3]([C:6]2[CH:20]=[CH:19][C:9]([CH2:10][CH2:11][NH:12]C(=O)C(F)(F)F)=[CH:8][CH:7]=2)[NH:4][CH:5]=1.[OH-].[Na+]>C1COCC1.CO.O>[N:1]1[N:2]=[C:3]([C:6]2[CH:7]=[CH:8][C:9]([CH2:10][CH2:11][NH2:12])=[CH:19][CH:20]=2)[NH:4][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178523136HCID 178523136, compound

Product 1

HCID 178510755HCID 178510755, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

A solution of N-(4-(4H-1,2,4-triazol-3-yl)phenethyl)-2,2,2-trifluoroacetamide (83 mg, 0.292 mmol) and NaOH (29 mg, 0.73 mmol) in a mixed solvent (THF/MeOH/H2O=2 mL/5 mL/1 mL) was stirred at RT for 2 h. The solvent was evaporated to dryness and the residue was submitted to flash chomatography (SiO2, EtOAc to EtOAc/2M NH3 in MeOH=100:20 to 100:50) to give 2-(4-(4H-1,2,4-triazol-3-yl)phenyl)-ethanamine as a colorless oil.

Workup

  1. customThe solvent was evaporated to dryness

Sources & evidence

ORD record
ord-9312cdf5e0784908885b6d397925b24b
Source dataset
uspto-grants-2010_02
Patent number
US07662811B2

Reaction notes

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