1,2-Dichloroethane → HCID 68678753, compound

Participants

Reaction Steps

To a 20 mL flask equipped with stirring was added N-[4-(3-oxo-propyl)-phenyl]-2-[3-oxo-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-pyrazin-2-yl]-acetamide (45 mg, 0.102 mmol), ClCH2CH2Cl (2 mL), piperidine (Aldrich, 0.02 mL, 0.204 mmol) and one drop of HOAc. NaBH(OAc)3 was added after 5 min. The reaction mixture was stirred at room temperature overnight, then diluted with CH2Cl2 (40 mL). The organic phase was washed with saturated NaHCO3 and brine, dried over Na2SO4, filtered and concentrated in vacuo. Purification by preparative TLC (10% MeOH—CH2Cl2) afforded the title compound. MS (ESI): 511 (M+H)+.

Provenance & Evidence