Triethylamine → Lansoprazole

Participants

Reaction Conditions

Reaction Steps

(i) 40 g (0.108 mole) 2-[[[3-methyl-4-(2,2,2-trifluoro-ethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole hydrate was dissolved in 120 ml of 1-methyl-2-pyrrolidone (NMP) at room temperature, then 0.263 g (1.077 mmole) of vanadium(V) oxytriisopropoxide were added and the reaction mixture was cooled to a temperature of from 0 to 5° C. 12.96 g (0.138 mole) of hydrogen peroxide urea adduct were suspended (optionally per partes) and the reaction was carried out at a temperature of from 0 to 10° C. for half an hour and then at a temperature of from 10 to 15° C. until the reaction was completed. At the end of the reaction, 5 ml of triethylamine and a solution of 5.68 g of sodium thiosulphate pentahydrate in 6 ml of water were added. The product was precipitated with water (280 ml at 20±5° C.) and filtered off to obtain 48.3 g of wet lansoprazole.

Provenance & Evidence