反应详情

68.8 g (367.4 mmol) N-methyl-N-pentyl-β-alanine methyl ester was hydrolyzed by refluxing with 138 ml water. Water was distilled off and 300 ml diethyl carbonate were added, followed by azeotropic distillation of diethyl carbonate/water (30 ml) to remove residual water. About 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine was obtained which could directly be used for the subsequent bisphosphorylation step.

1. distillationWater was distilled off
2. addition300 ml diethyl carbonate were added
3. distillationfollowed by azeotropic distillation of diethyl carbonate/water (30 ml)
4. customto remove residual water
5. additionAbout 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine
6. customwas obtained which