2,4-Dimethylphenol → 2-(2,4-Dimethylphenoxymethyl)-3-nitropyridine

HRID 1445034Notes

Reaction equation

HRID 1445034 reaction equation
Br[CH2:2][C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[OH:20]>>[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[O:20][CH2:2][C:3]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 77712,4-DimethylphenolHCID 218311782-(Bromomethyl)-3-nitropyridine

Product 1

HCID 671432272-(2,4-Dimethylphenoxymethyl)-3-nitropyridineYield 78%

Procedure

In accordance with the same procedures as in Step 3 of Preparation 1, except for using 2-bromomethyl-3-nitropyridine prepared in Step 2 of Preparation 1 and 2,4-dimethylphenol, the titled compound was obtained as yellow solid. (Yield: 78%)

Workup

  1. customIn accordance with the same procedures as in Step 3 of Preparation 1

Sources & evidence

ORD record
ord-8453e14c6f0740db98fceb7bc17eaba0
Source dataset
uspto-grants-2010_02
Patent number
US07662832B2

Reaction notes

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