N-(1-allyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-ylmethylene)-4-fluorophenylamine → N-[1-(1-allyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-2-phenylethyl]-4-fluorophenylamine hydrochloride

HRID 1445041Notes

Reaction equation

HRID 1445041 reaction equation
[CH2:1]([N:4]1[C:8]2=[C:9]([CH:13]=[N:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[N:10]=[CH:11][CH:12]=[C:7]2[C:6]([CH3:22])=[C:5]1[CH3:23])[CH:2]=[CH2:3].[CH2:24]([Mg][Cl:32])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[ClH:32].[CH2:1]([N:4]1[C:8]2=[C:9]([CH:13]([NH:14][C:15]3[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=3)[CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:10]=[CH:11][CH:12]=[C:7]2[C:6]([CH3:22])=[C:5]1[CH3:23])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 67141427N-(1-allyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-ylmethylene)-4-fluorophenylamineHCID 178418336HCID 178418336, compound

Product 1

HCID 67141466N-[1-(1-allyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-2-phenylethyl]-4-fluorophenylamine hydrochlorideYield 33%

Procedure

In accordance with the same procedures as in Step 2 of Example 135, except for using N-(1-allyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-ylmethylene)-4-fluorophenylamine prepared in Step 1 of Example 135 and benzylmagnesium chloride, the titled compound was obtained as a white solid. (Yield: 33%)

Sources & evidence

ORD record
ord-c8742f745553459480db7579c6774278
Source dataset
uspto-grants-2010_02
Patent number
US07662832B2

Reaction notes

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