4-Methylbenzylamine → 1-(2-methoxyethyl)-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochloride

HRID 1445046Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH2:14][O:15][CH3:16])[C:7]=12.[CH3:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][NH2:23])=[CH:20][CH:19]=1>>[ClH:1].[CH3:16][O:15][CH2:14][CH2:13][N:8]1[C:7]2=[C:2]([NH:23][CH2:22][C:21]3[CH:24]=[CH:25][C:18]([CH3:17])=[CH:19][CH:20]=3)[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]1[CH3:12]

Participants

Reactant 2

HCID 660354-Methylbenzylamine

HCID 11608396HCID 11608396, compound

Product 1

HCID 671429101-(2-methoxyethyl)-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochlorideYield 47%

Procedure

In accordance with the same procedures as in Step 3 of Example 198, except for using 7-chloro-1-(2-methoxyethyl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine prepared in Step 1 and 4-methylbenzylamine, the titled compound was obtained as a white solid. (Yield: 47%)

Sources & evidence

ORD record: ord-de383494a1cb4f0aac9ceb16194a4982
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07662832B2

Reaction notes

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