4-Methylbenzylamine → 1-(4-fluorobenzyl)-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochloride

HRID 1445050Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[C:7]=12.[CH3:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>>[ClH:1].[F:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][N:8]2[C:7]3=[C:2]([NH:27][CH2:26][C:25]4[CH:28]=[CH:29][C:22]([CH3:21])=[CH:23][CH:24]=4)[N:3]=[CH:4][CH:5]=[C:6]3[C:10]([CH3:11])=[C:9]2[CH3:12])=[CH:15][CH:16]=1

Participants

Reactant 2

HCID 660354-Methylbenzylamine

HCID 11701994HCID 11701994, compound

Product 1

HCID 671415601-(4-fluorobenzyl)-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochlorideYield 45%

Procedure

In accordance with the same procedures as in Step 3 of Example 198, except for using 7-chloro-1-(4-fluorobenzyl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine prepared in Step 1 and 4-methylbenzylamine, the titled compound was obtained as a white solid. (Yield: 45%)

Sources & evidence

ORD record: ord-3f2a5092e74047f6986460f1a9f51bab
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07662832B2

Reaction notes

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