4-Methylbenzylamine → 1-ethyl-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochloride

HRID 1445054Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH3:14])[C:7]=12.[CH3:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1>>[ClH:1].[CH2:13]([N:8]1[C:7]2=[C:2]([NH:21][CH2:20][C:19]3[CH:22]=[CH:23][C:16]([CH3:15])=[CH:17][CH:18]=3)[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]1[CH3:12])[CH3:14]

Participants

Reactant 2

HCID 660354-Methylbenzylamine

HCID 117082897-Chloro-1-ethyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine

Product 1

HCID 671410351-ethyl-2,3-dimethyl-7-(4-methylbenzylamino)-1H-pyrrolo[2,3-c]pyridine hydrochlorideYield 39%

Procedure

In accordance with the same procedures as in Step 3 of Example 198, except for using 7-chloro-1-ethyl-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine prepared in Step 1 and 4-methylbenzylamine, the titled compound was obtained as a white solid. (Yield: 39%)

Sources & evidence

ORD record: ord-bc8634c917964fc8a3c8d787fcaaf862
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07662832B2

Reaction notes

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