4-Fluorobenzylamine → 1-(3-fluorobenzyl)-7-(4-fluorobenzylamino)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine hydrochloride

HRID 1445060Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=3)[C:7]=12.[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>>[ClH:1].[F:20][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[CH2:13][N:8]1[C:7]2=[C:2]([NH:27][CH2:26][C:25]3[CH:28]=[CH:29][C:22]([F:21])=[CH:23][CH:24]=3)[N:3]=[CH:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]1[CH3:12]

Participants

Reactant 2

HCID 673264-Fluorobenzylamine

HCID 11644951HCID 11644951, compound

Product 1

HCID 671415321-(3-fluorobenzyl)-7-(4-fluorobenzylamino)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine hydrochlorideYield 70%

Procedure

In accordance with the same procedures as in Step 3 of Example 198, except for using 7-chloro-2,3-dimethyl-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine prepared in Step 1 and 4-fluorobenzylamine, the titled compound was obtained as a white solid. (Yield: 70%)

Sources & evidence

ORD record: ord-f51b567928a04f6bac24509ebd1e1792
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07662832B2

Reaction notes

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