反应详情

Sodium borohydride (4.7 mg, 0.124 mmol) was added to a solution of 7-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(3-fluorobenzyl)-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-carbaldehyde hydrochloride (25 mg) prepared in Example 616 in methanol (2 ml). The reaction mixture was stirred for 1 hour and water was added thereto. The reaction mixture was extracted with ethyl acetate and then concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (ethyl acetate/n-hexane=1/1, v/v). The resulting product was dissolved in ethyl acetate, saturated with hydrochloric acid gas, and then filtered to give 8 mg of the titled compound as a white solid.

1. extractionThe reaction mixture was extracted with ethyl acetate
2. concentrationconcentrated under reduced pressure
3. customThe resulting residue was purified with silica gel column chromatography (ethyl acetate/n-hexane=1/1
4. dissolutionThe resulting product was dissolved in ethyl acetate, saturated with hydrochloric acid gas
5. filtrationfiltered