Thiomorpholine → HCID 178428441, compound

HRID 1445100Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][N:6]1[C:10]2=[C:11]([N:18]3[CH2:27][CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19]3)[N:12]=[C:13]([C:15](O)=[O:16])[CH:14]=[C:9]2[C:8]([CH3:28])=[C:7]1[CH3:29].[NH:33]1[CH2:38][CH2:37][S:36][CH2:35][CH2:34]1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][N:6]1[C:10]2=[C:11]([N:18]3[CH2:27][CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19]3)[N:12]=[C:13]([C:15]([SH:36]3[CH2:37][CH2:38][NH:33][CH2:34][CH2:35]3)=[O:16])[CH:14]=[C:9]2[C:8]([CH3:28])=[C:7]1[CH3:29]

Participants

Reactant 2

HCID 67164Thiomorpholine

HCID 67142210HCID 67142210, compound

Product 1

HCID 178428441HCID 178428441, compoundYield 69%

Procedure

In accordance with the same procedures as in Example 756, except for using 1-(3-chlorobenzyl)-7-(3,4-dihydro-1H-isoquinolin-2-yl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-5-carboxylic acid prepared in Example 737 and thiomorpholine, the titled compound was obtained as a white solid. (Yield: 69%)

Sources & evidence

ORD record: ord-65a842cba2ab475ab97080ef76b34f93
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07662832B2

Reaction notes

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