Toluene → HCID 59021286, compound

Participants

Reaction Steps

To a mixture of 138 g of 1,1,1,3,3,5,5,5-octafluoro-2-(trifluoromethyl)pentane-2,4-diol (Synthesis Example [1-1]), 53.0 g of triethylamine, and 700 g of toluene, under ice cooling and with stirring, 45.4 g of methacrylic acid chloride was added dropwise. The mixture was stirred for 2 hours. Water was added to the reaction mixture to quench the reaction, followed by conventional work-up steps of washing, drying and concentration to give a crude product. It was purified by silica gel column chromatography, yielding 119 g (yield 71%) of the end compound, fluorinated ester.

Provenance & Evidence