Ethanol → HCID 178433876, compound

Participants

Reaction Conditions

Reaction Steps

2-(3,4-Dimethylphenyl)-4-{[2-hydroxy-3′-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one, 1.1 g of crude orange solid, in 7 mL of ethyl acetate and 12 mL of ethanol (190 proof) was stirred at approximately 40° C. To this suspension 2.5 ml of choline hydroxide (1N) solution in methanol was added resulting in a dark orange brown solution. Water (1 ml) was added to the dark solution and the mixture stirred at approx. 35° C. for approx. 3 hours. During this time, precipitation was seen in the solution. The suspension was stirred for another 72 hours at approx. 20° C., and then the solid was isolated by filtration and dried at approx. 40° C. over 12 hours to yield 1.2 gram (87% yield) of the title compound as a crystalline solid with a light orange color.

Provenance & Evidence