HCID 59644036, compound → HCID 24890884, compound

HRID 1445397Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:39]=[CH:38][C:6]([C:7]([O:9][C@@H:10]2[CH2:15][C@@H:14]([CH2:16][CH2:17][CH2:18][CH:19]=[CH2:20])[O:13][C@@:12]([O:36]C)([C@@H:21]3[CH2:25][S:24][C:23](=[O:26])[N:22]3CC3C=CC(OC)=CC=3)[CH2:11]2)=[O:8])=[CH:5][CH:4]=1.CO[C@]1([C@@H]2CSC(=O)N2CC2C=CC(OC)=CC=2)C[C@H]2C[C@@H](CCCC=CCCC(C)=CC(=O)O2)O1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([O:9][C@@H:10]2[CH2:15][C@@H:14]([CH2:16][CH2:17][CH2:18][CH:19]=[CH2:20])[O:13][C@@:12]([OH:36])([C@@H:21]3[CH2:25][S:24][C:23](=[O:26])[NH:22]3)[CH2:11]2)=[O:8])=[CH:38][CH:39]=1

Participants

Reactant 2

HCID 59644036HCID 59644036, compound

HCID 59644077(R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one

Product 1

HCID 24890884HCID 24890884, compound

Procedure

Application of the method shown in Example 46, with the modification that (2R,4R,6R)-2-methoxy-2-((R)-3-(4-methoxybenzyl)-2-oxothiazolidin-4-yl)-6-(pent-4-enyl)-tetrahydro-2H-pyran-4-yl 4-methoxybenzoate was substituted for (R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one, afforded the title compound.

Sources & evidence

ORD record: ord-5bac6bbb43f943b1b1d42c2f4b765c3d
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07666861B2

Reaction notes

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