HCID 59644069, compound → HCID 24888313, compound

HRID 1445398Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:41]=[CH:40][C:8]([C:9]([O:11][C@@H:12]2[CH2:17][C@@H:16]([CH2:18][CH2:19][CH2:20][CH:21]=[CH2:22])[O:15][C@@:14]([O:38]C)([C@@H:23]3[CH2:27][S:26][C:25](=[O:28])[N:24]3CC3C=CC(OC)=CC=3)[CH2:13]2)=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].CO[C@]1([C@@H]2CSC(=O)N2CC2C=CC(OC)=CC=2)C[C@H]2C[C@@H](CCCC=CCCC(C)=CC(=O)O2)O1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][C@@H:12]2[CH2:17][C@@H:16]([CH2:18][CH2:19][CH2:20][CH:21]=[CH2:22])[O:15][C@@:14]([OH:38])([C@@H:23]3[CH2:27][S:26][C:25](=[O:28])[NH:24]3)[CH2:13]2)=[O:10])=[CH:40][CH:41]=1)(=[O:3])=[O:4]

Participants

Reactant 2

HCID 59644069HCID 59644069, compound

HCID 59644077(R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one

Product 1

HCID 24888313HCID 24888313, compound

Procedure

Application of the method shown in Example 46, with the modification that (2R,4R,6R)-2-methoxy-2-((R)-3-(4-methoxybenzyl)-2-oxothiazolidin-4-yl)-6-(pent-4-enyl)-tetrahydro-2H-pyran-4-yl 4-(methylsulfonyl)benzoate was substituted for (R)-4-((1R,4Z,8Z,13R,15R)-15-methoxy-5-methyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadeca-4,8-dien-15-yl)-3-(4-methoxybenzyl)thiazolidin-2-one, afforded the title compound.

Sources & evidence

ORD record: ord-1aa64a150e3c4bdbb5444b5da356a79b
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07666861B2

Reaction notes

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