HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobutanal → 5-Ethyl-2-(4-methyl-2-nitro-phenyl)-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobutanal | HCID 12617811 | — |
| Reactant | 4-Methyl-2-nitro-thiobenzamide | HCID 54168808 | — |
| Product | 5-Ethyl-2-(4-methyl-2-nitro-phenyl)-thiazole | HCID 57666825 | 61% |
Reaction Steps
The procedure described in Example 15-1 was followed, except that 4-methyl-2-nitro-thiobenzamide (56) was used instead of 4-trifluoromethyl-2-nitro-thiobenzamide, and 2-bromo-butyraldehyde (54) was used instead of 1-bromo-3-methyl-butan-2-one, which gave the title compound (60 mg, 61%). LC/MS: (Method I): tR=1.52 min, >95%, m/z (ESI+)=249 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666834B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-fb586aba2aea4e328012fec6badf943d |
| Source note | uspto-grants-2010_02 |