Cyclopropanesulfonic Acid → [2-(4-Ethyl-thiazol-2-yl)-5-methyl-phenyl]-carbamic acid 13-methyl-4-(1-methyl-cyclopropanesulphonylaminocarbonyl)-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.04,6]octadec-7-en-17-yl ester

Participants

Role	Name	HCID	Charge
Reactant	Cyclopropanesulfonic Acid	HCID 10419166	—
Reactant	[2-(5-Ethyl-thiazol-2-yl)-5-methyl-phenyl]-carbamic acid 3-(hex-5-enyl-methyl-carbamoyl)-4-[1-(1-methyl-cyclopropanesulfonylamino-carbonyl)-2-vinyl-cyclopropylcarbamoyl]-cyclopentyl ester	HCID 66871250	—
Product	[2-(4-Ethyl-thiazol-2-yl)-5-methyl-phenyl]-carbamic acid 13-methyl-4-(1-methyl-cyclopropanesulphonylaminocarbonyl)-2,14-dioxo-3,13-diaza-tricyclo[13.3.0.04,6]octadec-7-en-17-yl ester	HCID 68676551	10%

Reaction Steps

The procedure described in Example 18-10 was followed, but using the compound prepared in Example 22 (112) (22 mg, 30 μmol) instead of the corresponding cyclopropanesulphonic acid derivative, which gave the title compound (2.1 mg, 10%). LC/MS (Method I): tr=2.41 min, >95%, m/z (ESI+)=712 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07666834B2
Source dataset	uspto-grants-2010_02
ORD ID	ord-608b3c95af1a4768ac2d02f52d5e67d8
Source note	uspto-grants-2010_02