HRID1445436

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12069538

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(Oc2cc(C(C)(C)C)ccc2C(=O)O)CC1

HCID68530505

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(=O)Nc2cnccc2NC(=O)c2ccc(C(C)(C)C)cc2OC2CCN(C(=O)OC(C)(C)C)CC2)cc1

HCID69492771

未命名化合物

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 101-D, 2-(N-Boc-piperidine-4-yloxy)-4-(tert-butyl)benzoic acid (1.0 g, 2.65 mmol) is converted into the acid chloride and used to acylate N3-(4-methoxybenzoyl)-3,4-pyridinediamine (600 mg, 2.47 mmol). After purification by chromatography (SiO2: 30% to 50% EtOAc in chloroform) 589 mg (40%) of the title compound is obtained.

WORKUP

后处理

customAfter purification by chromatography (SiO2: 30% to 50% EtOAc in chloroform) 589 mg (40%) of the title compound
customis obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9b6003131ca54a2cad14e1c2add5c747
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07666866B2
来源说明: uspto-grants-2010_02

反应 SMILES

[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:23]=[C:22]([C:24]([CH3:27])([CH3:26])[CH3:25])[CH:21]=[CH:20][C:16]=2[C:17]([OH:19])=O)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:28][O:29][C:30]1[CH:45]=[CH:44][C:33]([C:34]([NH:36][C:37]2[CH:38]=[N:39][CH:40]=[CH:41][C:42]=2[NH2:43])=[O:35])=[CH:32][CH:31]=1>>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:23]=[C:22]([C:24]([CH3:26])([CH3:25])[CH3:27])[CH:21]=[CH:20][C:16]=2[C:17]([NH:43][C:42]2[CH:41]=[CH:40][N:39]=[CH:38][C:37]=2[NH:36][C:34](=[O:35])[C:33]2[CH:32]=[CH:31][C:30]([O:29][CH3:28])=[CH:45][CH:44]=2)=[O:19])[CH2:10][CH2:9]1)=[O:2])([CH3:5])([CH3:6])[CH3:7]