N-(2-Aminophenyl)-4-methoxybenzamide → HCID 86628412, compound

Participants

Reaction Steps

In a manner substantially equivalent to Example 101-D, 2-(3-tert-butoxycarbonylamino-2,2-dimethylpropoxy)-4-methoxybenzoic acid (2.92 g, 8.25 mmol) and N1-(4-methoxybenzoyl)-1,2-benzenediamine (2.00 g, 8.25 mmol) were coupled. The crude material was dissolved in dichloromethane, and aminomethylated polystyrene was added to remove the unreacted acid chloride. The resin was filtered, the solution added directly to a SCX column (Varian, 60 cc/10 g, prewashed with MeOH), and the product washed through the column with 9:1 CHCl3:MeOH. Concentration of the wash in vacuo gave 3.50 g (73.4%) of a white foam.

Provenance & Evidence