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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1445473Generated: November 2, 2026

Hydrochloric Acid → 2-Cyclopropylquinazoline-6-carboxylic acid

https://huagongshe.com/reaction/1445473

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantIsopropanolHCID 3776—
ReactantPotassium HydroxideHCID 14797—
Reactant2-Cyclopropylquinazoline-6-carbonitrileHCID 23082042—
SolventWaterHCID 962—
Product2-Cyclopropylquinazoline-6-carboxylic acidHCID 68696270—

Reaction Steps

Into 8 ml of 2-propanol and 1 ml of water were dissolved 210 mg of 2-cyclopropylquinazoline-6-carbonitrile and 450 mg of potassium hydroxide, followed by heating under refluxing overnight. Hydrochloric acid was added thereto and the solvent was removed by evaporation to obtain the title compound as a crude carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07666873B2
Source datasetuspto-grants-2010_02
ORD IDord-76faad0f99e442e8a2355637b6cbbc63
Source noteuspto-grants-2010_02