HCID 86621687, compound → HCID 15986053, compound

HRID 1445486Notes

Reaction equation

HRID 1445486 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH:25]=[CH:24][C:23](/[CH:26]=[CH:27]/[C:28]([NH:30][O:31]C4CCCCO4)=[O:29])=[CH:22]3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1)(=[O:4])=[O:3]>CO>[OH:31][NH:30][C:28](=[O:29])/[CH:27]=[CH:26]/[C:23]1[CH:24]=[CH:25][N:21]([S:18]([C:15]2[CH:14]=[CH:13][C:12]([C:8]3[CH:9]=[CH:10][CH:11]=[C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])[CH:7]=3)=[CH:17][CH:16]=2)(=[O:19])=[O:20])[CH:22]=1

Participants

3

Reactant 1

HCID 86621687HCID 86621687, compound

Product 1

HCID 15986053HCID 15986053, compoundYield 41.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.334 g (E)-3-[1-(3′-methanesulfonylamino-biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 11.0 ml methanol and 18.0 ml 1M aqueous HCL is stirred for 48 h. The suspension is evaporated and the solid is isolated and washed with water and diisopropylether. The crude product is purified by PLC plates chromatography. By this method 0.116 g of a red solid are obtained. Melting point: 137-148° C.

Workup

  1. customThe suspension is evaporated
  2. customthe solid is isolated
  3. washwashed with water and diisopropylether
  4. customThe crude product is purified by PLC plates chromatography

Sources & evidence

ORD record
ord-c74048abd884468a9a59c3196a6e4c22
Source dataset
uspto-grants-2010_02
Patent number
US07666868B2

Reaction notes

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