HCID 86621688, compound → HCID 15986054, compound

HRID 1445487Notes

Reaction equation

HRID 1445487 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH:25]=[CH:24][C:23](/[CH:26]=[CH:27]/[C:28]([NH:30][O:31]C4CCCCO4)=[O:29])=[CH:22]3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:3]>CO>[OH:31][NH:30][C:28](=[O:29])/[CH:27]=[CH:26]/[C:23]1[CH:24]=[CH:25][N:21]([S:18]([C:15]2[CH:14]=[CH:13][C:12]([C:9]3[CH:10]=[CH:11][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:7][CH:8]=3)=[CH:17][CH:16]=2)(=[O:19])=[O:20])[CH:22]=1

Participants

3

Reactant 1

HCID 86621688HCID 86621688, compound

Product 1

HCID 15986054HCID 15986054, compoundYield 82.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.223 g (E)-3-[1-(4′-methanesulfonylamino-biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 6.0 ml methanol and 12.0 ml 1M aqueous HCL is stirred at ambient temperature for 24 h. The suspension is evaporated and the solid is washed with water and diisopropylether. The title compound is dried in vacuo. By this method 0.155 g light pink solid are obtained. Melting point: 160-167° C.

Workup

  1. customThe suspension is evaporated
  2. washthe solid is washed with water and diisopropylether
  3. dry with materialThe title compound is dried in vacuo

Sources & evidence

ORD record
ord-6669a84bc2ed4ded932c9c8d3efd5e8e
Source dataset
uspto-grants-2010_02
Patent number
US07666868B2

Reaction notes

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