Methanol → HCID 68528011, compound

HRID 1445489Notes

Reaction equation

HRID 1445489 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[S:11][C:10]([S:12]([N:15]3[CH:19]=[CH:18][C:17](/[CH:20]=[CH:21]/[C:22]([NH:24]OC4CCCCO4)=[O:23])=[CH:16]3)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[CH:4]=[N:3]1.C[OH:33]>>[OH:33]/[C:21](=[CH:20]/[C:17]1[CH:18]=[CH:19][N:15]([S:12]([C:10]2[S:11][C:7]([C:5]3[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=3)=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH:16]=1)/[C:22]([NH2:24])=[O:23]

Participants

3

Reactant 2

HCID 887MethanolHCID 86621690HCID 86621690, compound

Product 1

HCID 68528011HCID 68528011, compound

Procedure

A mixture of 0.099 g (E)-3-{1-[5-(1-methyl-1H-pyrazol-4-yl)-thiophene-2-sulfonyl]-1H-pyrrol-3-yl}-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 3.0 ml methanol and 6.0 ml 1M aqueous HCL is stirred at ambient temperature for 24 h. The suspension is filtered and washed with water and ethyl acetate. The title compound is dried in vacuo. By this method 0.037 g light pink solid are obtained. Melting point: 163-166° C.

Workup

  1. filtrationThe suspension is filtered
  2. washwashed with water and ethyl acetate
  3. dry with materialThe title compound is dried in vacuo

Sources & evidence

ORD record
ord-fae4a0d0cb084b629db96355e8ceef1a
Source dataset
uspto-grants-2010_02
Patent number
US07666868B2

Reaction notes

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