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HRID1445496

反应详情

EQUATION

反应方程式

HRID 1445496 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：CN1CCN(c2cc(B3OC(C)(C)C(C)(C)O3)ccn2)CC1
HCID2769537

1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine

C16H26BN3O2

结构：O=C(/C=C/c1ccn(S(=O)(=O)c2ccc(Br)cc2)c1)NOC1CCCCO1
HCID86621691

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCN(c2cc(-c3ccc(S(=O)(=O)n4ccc(/C=C/C(=O)NOC5CCCCO5)c4)cc3)ccn2)CC1
HCID86621699

未命名化合物

收率 64.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COCCOC
溶剂HCID8071

未命名化合物

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

(E)-3-[1-(4-Bromo-benzenesulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (6.8 g) and 1-methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine (5.0 g) are dissolved in DME (300 mL). Under an inert gas atmosphere are added (Ph3P)3PdCl2 (2.1 g) and 2M Na2CO3-solution (44 mL). The mixture is heated to 100° C. for 2.5 h. After filtration and extraction, the crude product from the organic phase is purified by silica gel flash chromatography. By means of chloroform/EtOH (30:1-19:1). 5.3 g of the title compound are obtained as brownish oil.

WORKUP

后处理

  1. filtrationAfter filtration and extraction
  2. customthe crude product from the organic phase is purified by silica gel flash chromatography