Imidazole → HCID 86612630, compound

HRID 1445561Notes

Reaction equation

HRID 1445561 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[CH:12]=[O:13].N1C=CN=C1.[C:19]1(=[O:25])[CH2:24][CH2:23][CH2:22][CH:21]=[CH:20]1>CO.O>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[CH:12]([OH:13])[C:21]1[CH2:20][C:19](=[O:25])[CH2:24][CH2:23][CH:22]=1

Participants

6

Reactant 3

HCID 795ImidazoleHCID 135942-Cyclohexen-1-oneHCID 11629787HCID 11629787, compound

Product 1

HCID 86612630HCID 86612630, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

The clear solution of Methyl 6-chloro-5-formyl-2-pyridincarboxylate (10 mmol, 1.99 g) and imidazole (10 mmol, 0.68 g) in 50 ml. of MeOH was slowly charged with 50 ml. of deionized water. To a stirred homogeneous reaction mixture was added 2-cyclohexen-1-one (10.2 mmol., 1.0 g) at room temperature and reaction progress was monitored by TLC. Upon completion of the reaction, excess MeOH was removed under reduced pressure, washed with water and extracted with CHCl3 thrice. Combined organic layers were washed with brine solution twice. The organic layer was concentrated and column chromatography of the crude product on silica gel, using 30% EtOAC in hexane as eluent, gave pure Baylis-Hillman adduct in 87% yield (2.56 g).

Workup

  1. customreaction progress
  2. customwas removed under reduced pressure
  3. washwashed with water
  4. extractionextracted with CHCl3 thrice
  5. washCombined organic layers were washed with brine solution twice
  6. concentrationThe organic layer was concentrated
  7. customgave pure Baylis-Hillman adduct in 87% yield (2.56 g)

Sources & evidence

ORD record
ord-8af9b7f4f9b740b3919fb260bc876378
Source dataset
uspto-grants-2010_02
Patent number
US07666883B2

Reaction notes

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