4-Fluoro-3-(trifluoromethyl)benzaldehyde → 1-Bromomethyl-4-ethanesulfonyl-2-trifluoromethyl-benzene

HRID 1445605Notes

Reaction equation

[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1Cl.FC1C=CC(C=O)=CC=1[C:23]([F:26])([F:25])[F:24].[CH2:27](S([O-])=O)C.[Na+]>>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH2:12][CH3:27])(=[O:11])=[O:10])=[CH:5][C:4]=1[C:23]([F:26])([F:25])[F:24]

Participants

Reactant 3

HCID 5222694-Fluoro-3-(trifluoromethyl)benzaldehyde

HCID 27610831-(Bromomethyl)-2-chloro-4-(methylsulfonyl)benzene

HCID 22986214Sodium ethanesulfinate

Product 1

HCID 672198351-Bromomethyl-4-ethanesulfonyl-2-trifluoromethyl-benzene

Procedure

The titled compound is prepared analogously to 1-bromomethyl-2-chloro-4-methanesulfonyl-benzene by replacing 2-chloro-4-fluorobenzaldehyde (step 90a) with 4-fluoro-3-trifluoromethylbenzaldehyde and by replacing sodium methanesulfinate with sodium ethanesulfinate.

Sources & evidence

ORD record: ord-904d8cb19ff2467788710eed94b3b302
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07666878B2

Reaction notes

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