4-Fluorobenzaldehyde → 1-(Bromomethyl)-4-(propane-2-sulfonyl)benzene

反応式

[Br:1]CC1C=CC(S(C)(=O)=O)=C(F)C=1.F[C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1.[Na+].[CH3:24][CH:25]([S:27]([O-:29])=[O:28])[CH3:26]>>[Br:1][CH2:19][C:18]1[CH:21]=[CH:22][C:15]([S:27]([CH:25]([CH3:26])[CH3:24])(=[O:29])=[O:28])=[CH:16][CH:17]=1

参加物

反応物 3

HCID 680234-Fluorobenzaldehyde

HCID 23685748Sodium propane-2-sulfinate

HCID 672190653-Fluoro-4-(methylsulphonyl)benzyl bromide

生成物 1

HCID 672197581-(Bromomethyl)-4-(propane-2-sulfonyl)benzene

実験手順

The titled compound is prepared analogously to 4-bromomethyl-2-fluoro-1-methanesulfonyl-benzene by replacing 3,4-difluorobenzaldehyde with 4-fluorobenzaldehyde and by replacing methane sulfinic acid sodium salt with 2-propane sulfinic acid sodium salt.

出典と根拠

ORDレコード: ord-b1996a14c7444e8db1346799124ffeb5
出典データセット: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07666878B2

反応ノート

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