Benzene, 1-isocyanato-2-methoxy- → HCID 56670450, compound

Participants

Reaction Steps

5.087 g (16.54 mmol) of the product of step 2 is dissolved in 80 ml tetrahydrofurane and 1.79 ml (16.5 mmol) 1-isocyanato-2-methoxy-benzene is added and stirred at room temperature. In order to trap excess isocyanate 0.3 equivalent 3-amino-1,2-propanediol is added and stirred for 2.5 hours. Then the reaction mixture is washed with saturated sodium hydrogen carbonate solution and brine, dried with Na2SO4 and partially evaporated. Crystallization give (6aR,9R)-9-(Pyrrolidine-1-carbonyl)-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-7-carboxylic acid (2-methoxy-phenyl)-amide. MS/ES: 457 (M+H)+

Provenance & Evidence