4-(Methanesulfonyl)phenylboronic acid → {2-[6-(4-Methanesulfonyl-phenyl)-pyridin-3-yl]-5-methyl-oxazol-4-yl}-acetic acid methyl ester

HRID 1445753Notes

Reaction equation

HRID 1445753 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8](B(O)O)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:14][O:15][C:16](=[O:31])[CH2:17][C:18]1[N:19]=[C:20]([C:24]2[CH:25]=[N:26][C:27](Cl)=[CH:28][CH:29]=2)[O:21][C:22]=1[CH3:23]>>[CH3:14][O:15][C:16](=[O:31])[CH2:17][C:18]1[N:19]=[C:20]([C:24]2[CH:25]=[N:26][C:27]([C:8]3[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=3)=[CH:28][CH:29]=2)[O:21][C:22]=1[CH3:23]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 58765666[2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester

Product 1

HCID 58951478{2-[6-(4-Methanesulfonyl-phenyl)-pyridin-3-yl]-5-methyl-oxazol-4-yl}-acetic acid methyl ester

Procedure

The titled compound is prepared substantially in accordance with the procedure of Example 4 using 4-(methanesulfonyl)benzene boronic acid and [2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester [CAS 478540-95-3].

Sources & evidence

ORD record
ord-ac3aee25e4dc4561a745ee36b4231c6c
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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