HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate → tert-Butyl (3R)-3-fluoropyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate | HCID 854055 | — |
| Reactant | (Bis(2-methoxyethyl)amino)sulfur trifluoride | HCID 2734690 | — |
| Reactant | tert-Butyl (3S)-3-fluoropyrrolidine-1-carboxylate | HCID 18453464 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl (3R)-3-fluoropyrrolidine-1-carboxylate | HCID 40430177 | — |
Reaction Steps
Prepare using the method of Intermediate 48 with N-Boc-(S)-(+)-3-pyrrolidinol (0.50 g, 2.67 mmol), [bis(2-methoxyethyl)amino]sulfur trifluoride (0.59 mL, 3.20 mmol) and anhydrous dichloromethane (4 mL) to give the title compound as a colourless oil (0.36 g): MS (m/e): 212 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-0b2be6b0167a49a795e99b18636c7920 |
| Source note | uspto-grants-2010_02 |