HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → (3R)-3-Fluoropyrrolidine 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | tert-Butyl (3R)-3-fluoropyrrolidine-1-carboxylate | HCID 40430177 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (3R)-3-Fluoropyrrolidine 4-methylbenzenesulfonate | HCID 86614634 | — |
Reaction Steps
Prepare using the method of Intermediate 49 with p-toluenesulfonic acid monohydrate (0.356 g, 1.87 mmol), tert-butyl (3R)-3-fluoropyrrolidine-1-carboxylate (See Intermediate50) (0.353 g, 1.87 mmol) and ethanol (2 mL) to give the title compound as a white solid (0.478 g): MS (m/e): 90 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-01a8d0991aae4cdda7c7671cd5579677 |
| Source note | uspto-grants-2010_02 |