HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → (3R)-3-Methoxypyrrolidine 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | (R)-3-Methoxypyrrolidine | HCID 15086791 | — |
| Reactant | (R)-tert-Butyl 3-methoxypyrrolidine-1-carboxylate | HCID 34179484 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (3R)-3-Methoxypyrrolidine 4-methylbenzenesulfonate | HCID 86614639 | — |
Reaction Steps
Prepare using the method of Intermediate 49 with p-toluenesulfonic acid monohydrate (0.207 g, 1.09 mmol), crude tert-butyl (3R)-3-methoxypyrrolidine-1-carboxylate and (3R)-3-methoxypyrrolidine (See Intermediate 58) (0.42 g, 1.09 mmol) and ethanol (2 mL) to give the title compound as a red solid (0.42 g): MS (m/e): 102(M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-33e9673998eb4534a32c95679252fa75 |
| Source note | uspto-grants-2010_02 |