4-(Chloromethyl)-1,3-thiazole hydrochloride → HCID 58951473, compound

HRID 1445785Notes

Reaction equation

HRID 1445785 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[N:7]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[O:9][CH:10]=1)[CH3:2].Cl.Cl[CH2:21][C:22]1[N:23]=[CH:24][S:25][CH:26]=1>>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[N:7]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:21][C:22]3[N:23]=[CH:24][S:25][CH:26]=3)=[CH:13][CH:12]=2)[O:9][CH:10]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 136021432HCID 136021432, compound2×

Product 1

HCID 58951473HCID 58951473, compound

Procedure

The title compound is prepared in a manner substantially similar to Intermediate 16 from [2-(4-Hydroxy-phenyl)-oxazol-4-yl]-acetic acid ethyl ester (See Intermediate 64) and 4-(chloromethyl)thiazole hydrochloride except KI (2 eq.) is also added. MS (m/e): 345.2 (M+1)

Workup

  1. additionis also added

Sources & evidence

ORD record
ord-0387f3a9a6244a3c8f7f0238d5071a52
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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