Sodium Carbonate → HCID 11625135, compound

Participants

Reaction Steps

2-(4-Bromo-phenyl-4-pyrrolidin-1-ylmethyl-oxazole hydrochloride (See Example 2) (0.151 g, 0.439 mmol), 4-methylsulfonylphenylboronic acid (0.132 g, 0.66 mmol), tetrakis-(triphenylphosphine) palladium (0.010 g, 0.009 mmol), aqueous sodium carbonate (2M, 0.88 mL, 1.76 mmol) and 7 mL of dioxane is placed in a 10 mL CEM microwave tube. The tube is placed in a CEM microwave reactor for 30 minutes at 90° C., 25 psi, and 45 watts of power. The mixture is cooled and concentrated to a dark residue which is purified by radial silica gel chromatography (1% 2M NH3 in MeOH/dichloromethane) to give 0.125 g of the titled compound. MS (m/e): 383.1 (M+1)

Provenance & Evidence