4-(Methanesulfonyl)phenylboronic acid → HCID 11619405, compound

HRID 1445797Notes

Reaction equation

HRID 1445797 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:23])=[C:11]([CH2:13][CH2:14][N:15]3[CH2:19][CH2:18][CH2:17][C@H:16]3[CH2:20][O:21][CH3:22])[N:12]=2)=[CH:4][CH:3]=1.[CH3:24][S:25]([C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)(=[O:27])=[O:26]>>[CH3:24][S:25]([C:28]1[CH:33]=[CH:32][C:31]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][C:10]([CH3:23])=[C:11]([CH2:13][CH2:14][N:15]4[CH2:19][CH2:18][CH2:17][C@H:16]4[CH2:20][O:21][CH3:22])[N:12]=3)=[CH:4][CH:3]=2)=[CH:30][CH:29]=1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 11567053HCID 11567053, compound

Product 1

HCID 11619405HCID 11619405, compound

Procedure

Starting with 2-(4-Bromo-phenyl)-4-[2-(S)-(+)-(2-methoxymethyl-pyrrolidin-1-yl)-ethyl]-5-methyl-oxazole (See Example 27) and 4-methylsulfonylphenylboronic acid, follow a procedure significantly analogous to Example 22 to give the titled compound. MS (m/e): 455.2 (M+1)

Sources & evidence

ORD record
ord-38a64a597c7f4fe1a02d15761bd113b3
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

Loading…