4-(Methanesulfonyl)phenylboronic acid → HCID 11525317, compound

HRID 1445798Notes

Reaction equation

HRID 1445798 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:23])=[C:11]([CH2:13][CH2:14][N:15]3[CH2:19][CH2:18][CH2:17][C@@H:16]3[CH2:20][O:21][CH3:22])[N:12]=2)=[CH:4][CH:3]=1.[CH3:24][S:25]([C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)(=[O:27])=[O:26]>>[CH3:24][S:25]([C:28]1[CH:33]=[CH:32][C:31]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][C:10]([CH3:23])=[C:11]([CH2:13][CH2:14][N:15]4[CH2:19][CH2:18][CH2:17][C@@H:16]4[CH2:20][O:21][CH3:22])[N:12]=3)=[CH:4][CH:3]=2)=[CH:30][CH:29]=1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 11682351HCID 11682351, compound

Product 1

HCID 11525317HCID 11525317, compound

Procedure

Starting with 2-(4-Bromo-phenyl)-4-[2-(R)-(+)-(2-methoxymethyl-pyrrolidin-1-yl)-ethyl]-5-methyl-oxazole (See Example 31) and 4-methylsulfonylphenylboronic acid, follow a procedure significantly analogous to that found in Example 22 to give the titled compound. MS (m/e): 455.2 (M+1)

Sources & evidence

ORD record
ord-f1d8747a469e4f578051f418911a7407
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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