3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 11676036, compound

HRID 1445803Notes

Reaction equation

HRID 1445803 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:5]=[C:6](B(O)O)[CH:7]=[CH:8][CH:9]=1.Br[C:16]1[CH:21]=[CH:20][C:19]([C:22]2[O:23][C:24]([CH3:34])=[C:25]([CH2:27][CH2:28][N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[N:26]=2)=[CH:18][CH:17]=1>>[CH3:34][C:24]1[O:23][C:22]([C:19]2[CH:20]=[CH:21][C:16]([C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:14])([F:13])[F:1])[CH:5]=3)=[CH:17][CH:18]=2)=[N:26][C:25]=1[CH2:27][CH2:28][N:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 11676036HCID 11676036, compound

Procedure

The title compound is prepared in a manner substantially analogous to Example 35 starting from 3-Trifluoromethoxybenzene boronic acid and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole. MS (m/e): 417.1 (M+1)

Sources & evidence

ORD record
ord-bb7461d74f234c6ea3e4b75929b1c54e
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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