3-(Methylsulfonyl)phenylboronic acid → 2-(3'-Methanesulfonyl-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

HRID 1445808Notes

Reaction equation

HRID 1445808 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7](B(O)O)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].Br[C:15]1[CH:20]=[CH:19][C:18]([C:21]2[O:22][C:23]([CH3:33])=[C:24]([CH2:26][CH2:27][N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)[N:25]=2)=[CH:17][CH:16]=1>>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[O:22][C:23]([CH3:33])=[C:24]([CH2:26][CH2:27][N:28]4[CH2:29][CH2:30][CH2:31][CH2:32]4)[N:25]=3)=[CH:17][CH:16]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 115316572-(3'-Methanesulfonyl-biphenyl-4-yl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Procedure

The title compound is prepared in a manner substantially analogous to Example 35 starting from 3-Methylsulfonylbenzene boronic acid and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole. MS (m/e): 411.1 (M+1)

Sources & evidence

ORD record
ord-b1cc180217ac4de584dc85d61ae244b4
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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