(Pyrimidin-5-yl)boronic acid → HCID 11522847, compound

HRID 1445811Notes

Reaction equation

HRID 1445811 reaction equation
[N:1]1[CH:6]=[C:5](B(O)O)[CH:4]=[N:3][CH:2]=1.Br[C:11]1[CH:16]=[CH:15][C:14]([C:17]2[O:18][C:19]([CH3:29])=[C:20]([CH2:22][CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[N:21]=2)=[CH:13][CH:12]=1>>[CH3:29][C:19]1[O:18][C:17]([C:14]2[CH:15]=[CH:16][C:11]([C:5]3[CH:6]=[N:1][CH:2]=[N:3][CH:4]=3)=[CH:12][CH:13]=2)=[N:21][C:20]=1[CH2:22][CH2:23][N:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 11522847HCID 11522847, compound

Procedure

The title compound is prepared in a manner substantially analogous to Example 45 starting from 5-Pyrimidine boronic acid and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole. MS (m/e): 335.2 (M+1)

Sources & evidence

ORD record
ord-3017e2f7db9545b6abcc410e474ec1d8
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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