5-Indolylboronic acid → HCID 11559756, compound

HRID 1445813Notes

Reaction equation

HRID 1445813 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6](B(O)O)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Br[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[O:21][C:22]([CH3:32])=[C:23]([CH2:25][CH2:26][N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[N:24]=2)=[CH:16][CH:15]=1>>[CH3:32][C:22]1[O:21][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:6]3[CH:5]=[C:4]4[C:9](=[CH:8][CH:7]=3)[NH:1][CH:2]=[CH:3]4)=[CH:15][CH:16]=2)=[N:24][C:23]=1[CH2:25][CH2:26][N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 27343615-Indolylboronic acidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 11559756HCID 11559756, compound

Procedure

The title compound is prepared in a manner substantially analogous to Example 45 starting from 5-Indole boronic acid and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole. MS (m/e): 372.2 (M+1)

Sources & evidence

ORD record
ord-ed238aec9fbc4215b919f6698bec0c0c
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

Loading…