Aluminium lithium hydride → HCID 11494564, compound

Participants

Reaction Steps

To a solution of 2-[2-(4-Benzyloxy-phenyl)-5-methyl-oxazol-4-yl]-1-(2-(R)-methyl-pyrrolidin-1-yl)-ethanone (See Intermediate 18) (0.62 g, 1.6 mmol) in THF (5 mL) at 0° C. is added a solution of lithium aluminum hydride in THF (1 M, 1.6 mL, 1.6 mmol). The cooling bath is removed, and the reaction mixture is allowed to warm to room temperature and stirred for 3.5 h. The reaction is quenched by the sequential addition of water (0.06 mL), 5 N NaOH (0.06 mL), and water (0.18 mL). The mixture is stirred at room temperature overnight and filtered. The solvent is removed in vacuo, and the crude product is obtained (0.49 g, 81%) and used without purification. MS (m/e): 377.2 (M+1)

Provenance & Evidence