HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,6-Dichloropyridazine → 3-Ethanesulfonyl-6-(4-{5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazol-2-yl}-phenyl)-pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,6-Dichloropyridazine | HCID 67331 | — |
| Reactant | Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester | HCID 11451238 | — |
| Reactant | 2-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol | HCID 58951431 | — |
| Reactant | 2-Ethanesulfonyl-5-iodo-pyridine | HCID 58951465 | — |
| Product | 3-Ethanesulfonyl-6-(4-{5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazol-2-yl}-phenyl)-pyridazine | HCID 11719137 | — |
Reaction Steps
The titled compound is prepared in substantial accordance with the procedures found in Example 4, Intermediate 22, Intermediate 13, and Example 75 using 2-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[ 1,3 ,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl }-ethanol (see Intermediate 3) and 3,6-Dichloro-pyridazine. MS (m/e): 441.3 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-56d5a0736ddf4a8c860763db343a0412 |
| Source note | uspto-grants-2010_02 |