HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-iodopyrimidine → 5-Methanesulfonyl-2-(4-{5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazol-2-yl}-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-iodopyrimidine | HCID 7006651 | — |
| Reactant | Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester | HCID 11451238 | — |
| Reactant | 2-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol | HCID 58951431 | — |
| Reactant | 2-Methanesulfonyl-5-iodo-pyridine | HCID 58951452 | — |
| Product | 5-Methanesulfonyl-2-(4-{5-methyl-4-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-oxazol-2-yl}-phenyl)-pyrimidine | HCID 68700022 | — |
Reaction Steps
The titled compound is prepared in substantial accordance with the procedures found in Example 4, Intermediate 33, Intermediate 13, and Example 75 using 2-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol (see Intermediate 3) and 5-bromo-2-iodo-pyrimidine. MS (m/e): 427.3 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-5169b8ddcdf84121aeb9db192b9dfa9e |
| Source note | uspto-grants-2010_02 |