Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester → HCID 68701352, compound

HRID 1445835Notes

Reaction equation

HRID 1445835 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:20])=[C:11]([CH2:13][CH2:14]OS(C)(=O)=O)[N:12]=2)=[CH:4][CH:3]=1.CC1O[C:25]([C:27]2C=C[C:30](B3OC(C)(C)C(C)(C)O3)=[CH:29][CH:28]=2)=[N:24]C=1CCO.Cl[C:46]1[CH:56]=[CH:55][C:49]([C:50]([N:52]([CH3:54])[CH3:53])=[O:51])=[CH:48][N:47]=1>>[CH3:53][N:52]([CH3:54])[C:50](=[O:51])[C:49]1[CH:55]=[CH:56][C:46]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][C:10]([CH3:20])=[C:11]([CH2:13][CH2:14][N:24]4[CH2:25][CH2:27][CH2:28][CH:29]4[CH3:30])[N:12]=3)=[CH:4][CH:3]=2)=[N:47][CH:48]=1

Participants

4

Reactant 3

HCID 11451238Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl esterHCID 123642316-Chloro-N,N-dimethylnicotinamideHCID 589514312-{5-Methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol2×

Product 1

HCID 68701352HCID 68701352, compound

Procedure

The titled compound is prepared substantially in accordance with the procedures of Example 4, Intermediate 13, and Example 75 using 2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol (see Intermediate 3) and 6-chloro-N,N-dimethyl-nicotinamide [CAS: 54864-83-4].

Sources & evidence

ORD record
ord-48972fc91e3a4f94bee5f524f3665d84
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Reaction notes

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