HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 11667756, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methanesulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester | HCID 11451238 | — |
| Reactant | HCID 86614637 | HCID 86614637 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 11667756 | HCID 11667756 | 100.6% |
Reaction Steps
Prepare using the method of Example 102 with 2-[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]ethyl methanesulfonate (See Intermediate 13) (0.17 g, 0.46 mmole), anhydrous acetonitrile (2 mL), potassium carbonate (0.25 g, 1.84 mmol), potassium iodide (0.008 g, 0.05 mmol) and (3S)-3-(fluoromethyl)pyrrolidine 4-methylbenzenesulfonate (salt) (See Intermediate 55) (0.19 g, 0.69 mmol) to give the title compound as a pale orange oil (0.17 g): MS (m/e): 367, 369(M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666871B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-882bc9c0cdef477fa9dbba6cf45846ba |
| Source note | uspto-grants-2010_02 |