Potassium Iodide → 2-(4-Bromophenyl)-4-{2-[(3R)-3-methoxypyrrolidin-1-yl]ethyl}-5-methyl-1,3-oxazole

Participants

Reaction Steps

Prepare using the method of Example 102 with 2-[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]ethyl methanesulfonate (See Intermediate 13) (0.32 g, 0.89 mmole), anhydrous acetonitrile (4 mL), potassium carbonate (0.43 g, 3.11 mmol), potassium iodide (0.015 g, 0.09 mmol) and (3R)-3-methoxypyrrolidine 4-methylbenzenesulfonate (salt) (See Intermediate 59) (0.25 g, 0.91 mmol) to give the title compound as a pale orange oil (0.25 g): MS (m/e) (79Br/81Br): 365, 367(M+1)

Provenance & Evidence